硝子体手術後の俯き姿勢へのアドヒアランスに関する検討

藤田保健衛生大

ENERGETICS APPROACH TO FATIGUE BEHAVIOR OF WOODEN JOINT USING DOUBLE-SIDED ADHESIVE TAPE

The authors have previously studied the possibility of the use of industrial double-sided adhesive tape as a method for jointing wooden panel to wooden framework. The mechanical performance of joints formed by such methods is comparable to that of nailed joint under static load conditions. However, the mechanical performance of such joints has not been evaluated under cyclic load conditions. This study was conducted to investigate this aspect of their performance. Double-shear specimens were prepared by bonding wooden panel to wooden framework using two types of adhesive tape with different substrates. Specimens were also prepared with wooden dowels to strengthen their jointing performance. The joint specimens were subjected to cyclic shear loading testing. The results of the tests were analyzed from an energetics perspective, and the shear deformability of the specimens at failure was estimated. The test results indicate that both the specimens formed using adhesive tape and those formed using wooden dowels had fatigue properties comparable to nailed joint specimens. A tendency for the shear deformability caused by cyclic loading to increase with the stress level was observed. It was possible to estimate the shear deformability by evaluating the energy absorption capacity of the joints from an energetics standpoint

Prevention of hypermelanosis by rearing Japanese flounder Paralichthys olivaceus in net-lined tanks

In artificially reared flatfish, especially the Japanese flounder Paralichthys olivaceus, pigmented skin (hypermelanosis) frequently appears on the fish’s blind side after normal metamorphosis. As no practical prevention method has yet been proposed, we examined the effectiveness of a loose net placed inside the rearing tank that covers the bottom and walls like a pouch. When juveniles (standard length [SL] 6 cm) were transferred to the net-lined tank (mesh size 4 mm) before the first appearance of hypermelanosis, the pigmented area after 2 months covered about 0.5% of the blind side; this is about 1/40th of the area covered by pigment in fish reared in an ordinary tank (20%). Although the initial appearance of pigmentation in the axilla area (the area covered by the pectoral fin) was not suppressed, utilization of a larger mesh size (12 mm) decreased the expansion of pigmentation in this area. Juveniles reared in the net-lined tank were about 5–15% smaller (SL) than those reared in the ordinary tank, but their body depth:SL ratio was closer to that of wild-caught juveniles. From the results of this study, we propose that net-lined rearing tanks with larger-sized mesh are a practical method of preventing hypermelanosis in Japanese flounder aquaculture systems

Involvement of activated transcriptional process in efficient gene transfection using unmodified and mannose-modified bubble lipoplexes with ultrasound exposure.

Recently, our group developed ultrasound (US)-responsive and mannose-modified gene carriers (Man-PEG(2000) bubble lipoplexes), and successfully obtained a high level of gene expression in mannose receptor-expressing cells following gene transfection using Man-PEG(2000) bubble lipoplexes and US exposure. We also reported that large amounts of plasmid DNA (pDNA) were transferred into the cytoplasm of the targeted cells in the gene transfection using this method. In the present study, we investigated the involvement of transcriptional processes on enhanced gene expression obtained by unmodified and Man-PEG(2000) bubble lipoplexes with US exposure. The transcriptional process related to activator protein-1 (AP-1) and nuclear factor-κB (NFκB) was activated by US exposure, and was founded to be involved in enhanced gene expression obtained by gene transfection using unmodified and Man-PEG(2000) bubble lipoplexes with US exposure. On the other hand, activation of AP-1 and NFκB pathways followed by US exposure was hardly involved in the inflammatory responses in the gene transfection using this method. These findings suggest that activation of AP-1 and NFκB followed by US exposure is involved in the enhanced gene expression using unmodified and Man-PEG(2000) bubble lipoplexes with US exposure, and the selection of pDNAs activated by US exposure is important in this gene transfection method

MEG Source Imaging and Group Analysis Using VBMEG

Variational Bayesian Multimodal EncephaloGraphy (VBMEG) is a MATLAB toolbox that estimates distributed source currents from magnetoencephalography (MEG)/electroencephalography (EEG) data by integrating functional MRI (fMRI) (https://vbmeg.atr.jp/). VBMEG also estimates whole-brain connectome dynamics using anatomical connectivity derived from a diffusion MRI (dMRI). In this paper, we introduce the VBMEG toolbox and demonstrate its usefulness. By collaborating with VBMEG's tutorial page (https://vbmeg.atr.jp/docs/v2/static/vbmeg2_tutorial_neuromag.html), we show its full pipeline using an open dataset recorded by Wakeman and Henson (2015). We import the MEG data and preprocess them to estimate the source currents. From the estimated source currents, we perform a group analysis and examine the differences of current amplitudes between conditions by controlling the false discovery rate (FDR), which yields results consistent with previous studies. We highlight VBMEG's characteristics by comparing these results with those obtained by other source imaging methods: weighted minimum norm estimate (wMNE), dynamic statistical parametric mapping (dSPM), and linearly constrained minimum variance (LCMV) beamformer. We also estimate source currents from the EEG data and the whole-brain connectome dynamics from the MEG data and dMRI. The observed results indicate the reliability, characteristics, and usefulness of VBMEG

Case Reports of TFE3-Rearranged Renal Cell Carcinoma: FDG-PET Uptake Might Help Diagnosis

Translocation and transcription factor E3 (TFE3)-rearranged renal cell carcinoma (RCC) is a rare subtype of RCCs characterised by the fusion of the TFE3 transcription factor genes on chromosome Xp11.2 with one of the multiple genes. TFE3-rearranged RCC occurs mainly in children and adolescents, although middle-aged cases are also observed. As computed tomography (CT)/magnetic resonance imaging (MRI) findings of TFE3-rearranged RCC overlap with those of other RCCs, differential diagnosis is often challenging. In the present case reports, we highlighted the features of the fluorine-18-labelled fluorodeoxyglucose positron emission tomography with CT (FDG PET-CT) in TFE3-rearranged RCCs. Due to the rarity of the disease, FDG PET-CT features of TFE3-rearranged RCC have not yet been reported. In our cases, FDG PET-CT showed high standardised uptake values (SUVmax) of 7.14 and 6.25 for primary tumours. This might imply that TFE3-rearranged RCC has high malignant potential. This is conceivable when the molecular background of the disease is considered in terms of glucose metabolism. Our cases suggest that a high SUVmax of the primary tumour is a clinical characteristic of TFE3-rearranged RCCs

Cervical Ossification of Posterior Longitudinal Ligament in X-Linked Hypophosphatemic Rickets Revealing Homogeneously Increased Vertebral Bone Density

There is no report that describes in detail the radiological and intraoperative findings of rickets with symptomatic cervical ossification of the posterior longitudinal ligament. Here, we describe a case of X-linked hypophosphatemic rickets with cervical ossification of the posterior longitudinal ligament presenting unique radiological and intraoperative findings. The patient presented progressive tetraparesis. Magnetic resonance imaging studies revealed severe cervical spinal cord compression caused by ossification of the posterior longitudinal ligament. Computed tomography scans revealed homogeneously increased vertebral bone density. An expansive laminoplasty was performed. At surgery, homogeneously hard lamina bone was burdened in drilling and opening of the laminae. The patient's neurological symptoms were improved postoperatively. Bony fusion of the hinges occurred postoperatively. Therefore, expansive laminoplasty could be performed for symptomatic cervical ossification of the posterior longitudinal ligament with X-linked hypophosphatemic rickets. However, unusual bone characters should be taken into consideration for careful operation during surgery

Implementation of a Strongly Robust Identity-Based Encryption Scheme over Type-3 Pairings

Identity-based encryption (IBE) is a powerful mechanism for maintaining security. However, systems based on IBE are unpopular when compared with those of the public-key encryption (PKE). In our opinion, one of the reasons is a gap between theory and practice. For example, a generic transformation of weakly/strongly robust IBE from any IBE has been proposed by Abdalla et al., no robust IBE scheme is explicitly given. This means that, theoretically, anyone can construct a weakly/strongly robust IBE scheme by employing this transformation. However, this seems not easily applicable to non-cryptographers. In this paper, we first introduce the Gentry IBE scheme constructed over Type-3 pairings by employing the transformation proposed by Abe et al., and second we explicitly give strongly/weakly robust Gentry IBE schemes by employing the Abdalla et al. transformation. Finally, we show its implementation result and show that we can add strong robustness to the Gentry IBE scheme with a very few additional costs. We employ the mcl library to support a Barreto-Naehrig curve defined over the 462-bit prime. The encryption requires about 5 ms, whereas the decryption requires about 9 ms

An Online Experimental Framework for Cooperative Relationships With a Real-Time Decision-Making and Rewarding Environment

This paper investigates interactions between game theoretical strategies and social relationships in real-time decision-making and rewarding environments. We propose an experimental framework based on techniques of web-based multiplayer online games for this purpose. In our framework, multiple human players, represented as particles in a two-dimensional space of social interactions, can modify their positions and game strategies for the prisoner's dilemma in real time, and receive benefit or cost emerging from both game theoretical and social relationships with neighboring players. We report on experiments with human participants in different conditions of the payoff matrix, which reflects game structures, and the speed of each player, which reflects the ability to change her social relationship. We show that cooperative relationships emerge in real human groups regardless of experimental settings, and show their basic behavioral patterns. We further discuss relationships between behavioral characters of participants in the experiments and their psychological characters to see how their personalities can be reflected in their behavior in such a game theoretical framework, and show that a few psychological characters of participants might reflect their behavioral characters at least in part, but there were variations in these relationships between experimental groups